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EXCMastiffs

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Reply with quote  #101 
I have the iSearchiGive toolbar at home, and the iSearchiGive home page at work for any internet searching I do - and my stats state I have raised $4.31 since September 1 just by searching!

It's a great way to get money for the cause!

Heather

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Excelsior Mastiffs
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EXCMastiffs

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Reply with quote  #102 
iGive is now giving .02 for searches!

I just started using it for searches in August and have already raised $10.29 for Mastiff Club of America Charitable Health Trust! 

You can also raise other $ by linking to places you would already shop through their site... especially important now that the holiday season is almost here!

Heather

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steveoifer

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Reply with quote  #103 
Sent to me today from Anna May............

EXCITING NEWS!

Below is a copy of the Lay Summary for the most recent Cystinuria Grant # 919 that ended on 12-31-09.  As you can see, we've made significant progress in the past 6 months!  It's been a group effort and we appreciated the Mastiff Community and other breeds for participating in the research!

Dr. Henthorn will be submitting an Acorn Grant this month to the AKC CHF to continue her Canine Cystinuria Research.  We are hoping this will lead to a DNA test for Cystinuria in Mastiffs and other breeds and help us identify which dogs are at a higher risk of developing stones.  We are also hoping the research will help us better understand the disease and help us decrease stone formation in those dogs...

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CHF Grant 919 - "Molecular Genetic Characterization of Canine Cystinuria
for the Development of Carrier Tests"

Lay Summary (Non-confidential)

Cystinuria is an inherited disorder that causes kidney and urinary tract
stones in dog, man and other animals and has been documented in over 60
breeds of dogs. In humans, mutations in the protein coding regions of
two genes (named SLC3A1 and SLC7A9) are found in affected individuals.
In humans, cystinuria is primarily inherited as an autosomal recessive
trait, with some instances of somewhat more complex inheritance
patterns. In many dog breeds, cystinuria appears much more complex.
While our data rules out simple autosomal recessive inheritance of
mutations changing the proteins produced by SLC3A1 or SLC7A9, our most
recent data suggests that in at least one breed of dogs (Mastiffs), DNA
changes near one of these genes are associated with cystine stone
formation. There is also evidence that gender and reproductive status
may affect the level of cystine in the urine. Taken together and if
confirmed in a more comprehensive study, this most recent data suggests
approaches that can be used to reduce the incidence of cystine stone
formation in the Mastiff breed. Additional studies can be pursued to
determine if the conclusions reached in Mastiffs can be extended to
other breeds, and may help identify the underlying biological processes
leading to cystine stone formation in several dog breeds.

***********************************************

If you would like to send a tax deductible donation to help us support Cystinuria Research and other Mastiff Health related programs, please write your checks payable to The MCOA Charitable Trust and mail the donation to:
MCOA Charitable Health Trust
c/o Anne Heyob
1345 Murphy Hill Road, Lot 182
Langston, AL 35755

You can also make an online donation to the Mastiff Club of America's Charitable Trust through
If you would like to make a donation designated to the MCOA Charitable Trust's Cystinuria Account you can send your checks to the above address and write "Cystinuria Account" in the notes section. 
 
You can also make an online donation designated to the MCOA Charitable Trust's Cystinuria Account through our Facebook Cause at: http://www.causes.com/donations/select_donation_method?cause_id=341845
 
Once we have a DNA test for Cystinuria in Mastiffs we will use the remaining funds in the Cystinuria Account as needed to help support other health related programs. 
 
ALL donations are greatly appreciated!

If you would like to make a large donation or would like to be listed as a direct Sponsor of the new Cystinuria Grant or other upcoming Health Grants, you can contact Anna May at mastiff@iinet.com for more information.
Please continue to submit blood and urine samples to the University of Pennsylvania from Mastiffs that are Cystinuria positive!   The research can only continue with your help!

HAPPY NEW YEAR!

MCOA Cystinuria Committee
http://www.mastiff.org/CYSTINURIA.htm

***********************************************

 PERMISSION TO CROSS POST!



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For the betterment of the breed

"Above all, a uniform type should be aimed at by breeders and uniformity of type can only exist in a proportionate ratio in the purity and distinctiveness in any breed"!.........M. Moore
"If breeds did not adhere to a specific shape, form, and colour range, or if breeders disregarded this blueprint, the breed would degenerate to the point that it would hardly resemble the breed at all. Selective breeding does not just create breeds- it preserves them as well." Breeding purebred dogs inherently means accepting limitations on your freedom to just breed anything...Catherine McMillan
" A reinforced consolidation of the American and British standards could be the basis for restoring our breed to the gladiatorial glory of its ancient past, in capability if not in usage".....Norman Howard Carp-Gordon
"I can live with doubt, or not knowing, rather than to have answers that might be wrong"...Richard Feynman
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